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Secondary Bacterial Infections of Acute Bronchitis: Four randomized, controlled clinical studies were performed comparing 5 days versus 10 days of cefuroxime axetil for the treatment of patients with secondary bacterial infections of acute bronchitis.

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Like all antibiotics, it is not useful for the treatment of viral infections.

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Taking the full course is important (even if you feel your infection has cleared up) in order to prevent the infection from coming back.

Considering regional microbial sensitivities is also important when choosing any antimicrobial agent for the treatment of infection.

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The single-dose doxycycline trial was incapable of measuring the effectiveness of a single 200 mg dose of doxycycline for Lyme disease prevention because outcome measurements were limited to documenting the occurrence of an EM rash at the bite site as opposed to all disease manifestations 62.

The 11 patients with hearing impairment did not differ from the other 92 study patients in their demographic profile, severity and course of disease, or results on the initial and repeat examinations of cerebrospinal fluid (cell counts and protein and glucose levels).

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Gram stains are inadequate for evaluating prepubertal children for gonorrhea and should not be used to diagnose or exlude gonorrhea.

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In children, the most common organisms were H influenzae (40%), M catarrhalis (34%), and S pneumoniae (50%), a marked difference from findings in adults.

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Such a trend is based on the growing use of genomic information together with in silico prediction of useful antigens and massive production of recombinant proteins to be used for immunization of animal models ().

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Choosing monotherapy instead of combination therapy reduces costs associated with administering an antibacterial.

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In addition, long-term antibiotic treatment carries its own serious risks, such as the development of antibiotic-resistant superbugs.

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In this regard, we have reviewed the genetic linkage of antibiotic resistance and bacterial virulence in the same genetic determinants as well as the cross talk between antibiotic resistance and virulence regulatory circuits with the aim of understanding the effect of acquisition of resistance on bacterial virulence.

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In this regard, the record of infectious diseases (mainly epidemic ones) in human history and bioarchaeological analysis of the paleontological record indicate that we have been in contact with pathogens similar to those currently producing infections for a long time.

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Of the patients with satisfactory outcomes at 1 month posttreatment who were evaluable at 1 year posttreatment, a satisfactory outcome was achieved in 62 of 65 (95%) and in 53 of 53 (100%) patients treated with cefuroxime axetil and doxycycline, respectively (difference, -5%; 95% confidence interval, -10 to 4%).

This economic study was conducted to compare the cost-effectiveness of azithromycin vs cefuroxime with or without erythromycin for the treatment of adult patients hospitalized with CAP.

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As empiric therapy, azithromycin monotherapy was cost-effective compared to cefuroxime with or without erythromycin for patients hospitalized with CAP who have no underlying cardiopulmonary disease, and no risk factors for either drug-resistant pneumococci or enteric Gram-negative pathogens.

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In assessing the balance between the risks and benefits of antibiotic treatments for Lyme disease, the panel weighed the burden of disease, the magnitude and relative importance of patient-centered outcomes as well as treatment-associated risks and the risks attendant on not treating.

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However, patients wishing to avoid antibiotics may prefer this option, in which case clinicians should emphasize that patients must immediately report the occurrence of Lyme-related symptoms so that appropriate antibiotic therapy can be instituted.

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Although 15 years of CDC surveillance data documented that 31% of reported surveillance cases lacked an EM rash 63.

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