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Key words used were: diclofenac potassium, diclofenac sodium, NSAID, indication, therapeutic index, solubility, polymorphism, partition coefficient, p K a, absorption, permeability, distribution, metabolism, excretion, excipients, bioequivalence and dissolution.

The reaction is heated as described in the above reference and worked up using conditions as described to afford B-2.

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Together, these properties tend to lessen the undesirable gastrointestinal adverse effects related to traditional NSAIDs, including diclofenac sodium, a drug that has been used as an analgesic for pediatric patients undergoing tonsillectomy and adenoidectomy.

The methods described herein contemplate the use of tranilast in combination with other agents to treat or prevent rheumatoid arthritis.

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Hence, it is inferred that none of the excipients tabulated in these tables has had a significant effect on the extent nor the rate of diclofenac absorption.

The data would imply that patients requiring NSAID treatment for chronic inflammatory conditions such as arthritis, could use hyperimmunized egg product, hyperimmunized milk product, or a combination of the two along with their usual dosage of NSAID and experience a reduction in the typical NSAID-induced gastrointestinal side effects.

The studies support the concept that the hyperimmunized egg and milk products have a cytoprotective effect capable of reducing NSAID-induced gastrointestinal adverse effects.

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